Two-stage meta-analysis of survival data from individual participants using percentile ratios

نویسندگان

  • Jessica K Barrett
  • Vern T Farewell
  • Fotios Siannis
  • Jayne Tierney
  • Julian P T Higgins
چکیده

Methods for individual participant data meta-analysis of survival outcomes commonly focus on the hazard ratio as a measure of treatment effect. Recently, Siannis et al. (2010, Statistics in Medicine 29:3030-3045) proposed the use of percentile ratios as an alternative to hazard ratios. We describe a novel two-stage method for the meta-analysis of percentile ratios that avoids distributional assumptions at the study level.

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عنوان ژورنال:

دوره 31  شماره 

صفحات  -

تاریخ انتشار 2012